The Effect of Isatin beta Thiosemicarbazone (IBT)-related Compounds on IBT-resistant and on IBT-dependent Mutants of Vaccinia Virus

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Synthesis of vaccinia viral antigens in HeLa cells in the presence of isatin beta-thiosemicarbazone.

Vaccinia virus antigens, in HeLa cells treated with the antipox virus drug isatin beta-thiosemicarbazone (IBT), were analyzed by immunoprecipitation, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The total radioactivity in the immunoprecipitate was decreased to almost 50% in the presence of the drug as compared to its absence. An inhibition also occurred with an IBT-dep...

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 1974

ISSN: 0022-1317,1465-2099

DOI: 10.1099/0022-1317-25-2-239